Thermo Fisher Scientific NF-kB p105/p50 Polyclonal Antibody
NF-kB p105/p50 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 인간 및 마우스 시료 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. 세포 성장, 분화, 염증 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from C-terminus of NFkBp100/p50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: All human tissue
- Cellular location: Nucleus, Cytoplasm
Target Information
NF-kB is a nuclear transcription factor activated by various extra- and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates cellular events including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, is synthesized as a p105 precursor protein containing an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65 to create the functional NF-kB complex, directing nuclear translocation and DNA binding.
NF-kB has been implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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