Thermo Fisher Scientific NTHL1 Polyclonal Antibody
NTHL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 산화적 DNA 손상 복구 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human NTH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792325 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (80%), Rat (80%), Bovine (82%).
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Oxygen radicals damage chromosomal DNA, causing cell death and mutations. While much research has focused on repairing 8-oxo-G lesions, free radicals create various other damaged DNA sites.
The human NTH1 repair protein acts on many of these oxidatively damaged DNA sites.
A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity.
NTH protein has broad substrate specificity, including numerous pyrimidine ring saturation and fragmentation products.
Research indicates NTH plays a crucial role in the removal of oxidative base lesions in mitochondrial DNA.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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