Thermo Fisher Scientific NTHL1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (80%), Rat (80%), Bovine (82%).
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Oxygen radicals damage chromosomal DNA, causing cell death and mutations. While much research has focused on repairing 8-oxo-G lesions, free radicals create various other damaged DNA sites.
The human NTH1 repair protein acts on many of these oxidatively damaged DNA sites.
A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity.
NTH protein has broad substrate specificity, including numerous pyrimidine ring saturation and fragmentation products.
Research indicates NTH plays a crucial role in the removal of oxidative base lesions in mitochondrial DNA.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.