Thermo Fisher Scientific Phospho-IGF1R (Tyr980) Polyclonal Antibody
IGF1R의 Tyr980 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적합하며 인간 및 마우스 반응성. 고순도 정제, 액상 형태로 안정적이며 -20°C 보관.
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Thermo Fisher Scientific Phospho-IGF1R (Tyr980) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human IGF1R (Accession P08069), corresponding to amino acid residues around phosphorylated Tyr980 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817253 |
Product Specific Information
Antibody detects endogenous levels of IGF1 Receptor only when phosphorylated at Tyr980.
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2. It plays a role in various cancers and consists of two alpha and two beta subunits. The alpha subunits bind IGF-1 with higher affinity than IGF-2, leading to receptor conformational change and autophosphorylation at residues 1134, 1135, and 1136. Activated IGF-1R phosphorylates substrate proteins, initiating RAS/RAF/MAPK signaling cascades (ERK, p38, JNK), resulting in gene transcription that promotes proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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