Thermo Fisher Scientific GABRA1 Polyclonal Antibody
GABRA1 단백질을 표적하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 마우스 및 랫트 시료에 반응합니다. Western blot에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 신경전달 관련 연구에 유용한 연구용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of mouse GABA A Receptor alpha 1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2735794 |
Product Specific Information
- Positive Control: Mouse cerebellum, rat cerebellum
- Predicted Reactivity: Human (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases including epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex with multiple alpha, beta, and gamma subunits, including splice variants. Expression of alpha- and beta-subunits results in functional GABAA-R sensitive to GABA, while coexpression of a gamma-subunit is required for benzodiazepine modulation.
Phosphorylation of beta-subunits has been shown to modulate GABAA-R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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