Thermo Fisher Scientific Phospho-NMDAR2B (Tyr1472) Polyclonal Antibody
Phospho-NMDAR2B (Tyr1472)에 특이적인 Rabbit Polyclonal Antibody로, Mouse와 Rat 시료에 반응합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Rat NMDAR2B (phospho Tyr1472). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.86 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2736394 |
Product Specific Information
- Positive Control: Mouse brain, Rat brain
- Predicted Reactivity: Human (100%), Dog (100%), Bovine (100%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency associated with learning and memory.
NMDAR2B plays a role in neuronal development and is implicated in several central nervous system disorders, including Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit is linked to enhanced learning and memory, whereas reduced NR2B expression is observed in aged, memory-impaired animals.
Phosphorylation at Tyr1472 may increase NMDAR expression at the synapse, contributing to synaptic plasticity. NMDR2B is a heterotrimer composed of NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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