Thermo Fisher Scientific BTRC Monoclonal Antibody (OTI1A4), TrueMAB
BTRC 단백질을 인식하는 마우스 단클론 항체로 Western Blot 및 면역세포염색에 사용 가능. Human 시료에 반응하며, 고순도 친화 크로마토그래피로 정제됨. PBS, BSA, 글리세롤 완충액에 보관되며 -20°C에서 안정적 저장 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Human fragment corresponding to amino acids 52–354 of human BTRC produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid F-box motif. F-box proteins form part of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
F-box proteins are classified into three groups:
- Fbws containing WD-40 domains
- Fbls containing leucine-rich repeats
- Fbxs with other or no recognizable motifs
The encoded BTRC protein belongs to the Fbws class and includes multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins.
BTRC interacts with HIV-1 Vpu, linking CD4 to the proteolytic machinery, and binds phosphorylated IkappaBalpha and beta-catenin destruction motifs. It functions in transcriptional regulation by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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