Thermo Fisher Scientific VISTA/GI24 (Negative Regulator of Immune Response) Monoclonal Antibody (VISTA/2864)
인간 VISTA 단백질을 인식하는 마우스 단클론 항체로 면역반응 조절 연구에 적합함. ELISA 및 Peptide Array 등 다양한 어세이에 사용 가능. 단백질 A/G로 정제된 액상형 항체로 안정적인 품질 제공. 암 면역치료 타깃 연구용으로 권장됨.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VISTA/2864 |
| Immunogen | Recombinant full-length human VISTA protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mouse and human, VISTA is predominantly expressed on hematopoietic cells, with the highest densities on myeloid cells and lower levels on T cells, while it is typically absent on B cells.
VISTA expressed by antigen-presenting cells can directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy. Reported ligands include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 64115-MSM4-P0_VISTA_Q9H7M9-1_House_mouse.svg, 64115-MSM4-P0_VISTA_Q9H7M9-1_House_mouse_PDP.jpeg)
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