Thermo Fisher Scientific VISTA/GI24 (Negative Regulator of Immune Response) Monoclonal Antibody (VISTA/3006)
인간 VISTA 단백질을 인식하는 단클론 항체로 면역조직화학, ELISA, 펩타이드 어레이 등 다양한 연구용 분석에 적합함. 단백질 A/G로 정제된 액상 형태이며, 4°C에서 보관. 면역반응 조절 연구 및 암 면역치료 표적 연구에 활용 가능.
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Thermo Fisher Scientific VISTA/GI24 (Negative Regulator of Immune Response) Monoclonal Antibody (VISTA/3006)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VISTA/3006 |
| Immunogen | Recombinant full-length human VISTA protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mouse and human, VISTA is predominantly expressed on hematopoietic cells—most abundantly on myeloid cells, and at lower levels on T cells—while it is typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it an important target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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