Thermo Fisher Scientific VISTA/GI24 (Negative Regulator of Immune Response) Monoclonal Antibody (VISTA/3006)
인간 VISTA 단백질을 인식하는 마우스 단일클론 항체입니다. 다양한 면역조직화학(IHC), ELISA, Peptide Array에 사용 가능합니다. 암 면역치료 연구 등 면역 반응 조절 관련 연구용으로 적합합니다. 단백질 A/G 정제, PBS 저장, 보존제 무첨가.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VISTA/3006 |
| Immunogen | Recombinant full-length human VISTA protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is encoded by the VSIR gene. Although VISTA shares sequence homology with PD-L1, its expression pattern differs.
In both mouse and human, VISTA is predominantly expressed on hematopoietic cells—highest on myeloid cells and lower on T cells, typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it a key target for cancer immunotherapy.
Reported ligands include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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