Thermo Fisher Scientific Phospho-ULK1 (Thr1046) Polyclonal Antibody
ULK1 단백질의 Thr1046 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 검증됨. 자가포식 관련 연구에 적합하며, 고순도 액상 형태로 제공. -20°C 보관.
- 카탈로그번호
- PA5105423
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ULK1 (Accession O75385), corresponding to amino acid residues around phosphorylated Thr1046 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816851 |
Product Specific Information
This antibody detects endogenous levels of ULK1 only when phosphorylated at Thr1046.
Target Information
ULK1 is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy, a vital cellular response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 regulates its function and localization. Knockdown of ULK1 inhibits both the autophagic response and rapamycin-induced autophagy, consistent with its role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13, which is essential for starvation-induced autophagy. Both FIP200 and ATG13 are crucial for proper ULK1 localization to the pre-autophagosome and for ULK1 protein stability. ULK1 phosphorylation is regulated by the mTOR pathway in response to nutrient conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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