Thermo Fisher Scientific Phospho-ULK1 (Ser556) Polyclonal Antibody
ULK1 단백질의 Ser556 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(P)에서 사용 가능. 자가포식 연구 및 mTOR 경로 분석에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ULK1 (Ser556) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ULK1 (Accession O75385), corresponding to amino acid residues around phosphorylated Ser556. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816850 |
Product Specific Information
This antibody detects endogenous levels of ULK1 only when phosphorylated at Ser555 of mouse ULK1 or Ser556 of human ULK1.
Target Information
ULK1 is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy, a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls its regulatory function and localization. Knockdown of ULK1 inhibits the autophagic response and rapamycin-induced autophagy, consistent with its role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13, essential for starvation-induced autophagy. Both FIP200 and ATG13 are required for correct localization of ULK1 to the pre-autophagosome and for ULK1 protein stability. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.