Thermo Fisher Scientific CIB4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CIB4. Recombinant protein control fragment (Product #RP-96159). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CIB4,uniProtId:A0PJX0-1,ncbiNodeId:9606,antigenRange:96-185,antigenLength:185,antigenImageFileName:PA5-57532_CIB4_A0PJX0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57532_CIB4_A0PJX0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639819

Product Specific Information

Immunogen sequence: ACPSLKIEYA FRIYDFNENG FIDEEDLQRI ILRLLNSDDM SEDLLMDLTN HVLSESDLDN DNMLSFSEFE HAMAKSPDFM NSFRIHFWGC

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.

Target Information

CIB4 (calcium and integrin-binding family member 4) is a 185 amino acid protein that contains three EF-hand domains. CIB4 is closely related to CIB (CIB has one less EF-hand domain), which is known to bind to Integrin alpha II beta in platelets and is involved in signal transduction. The gene encoding CIB4 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorders itosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstrom syndrome, is caused by mutationsin the ALMS1 gene, which maps to chromosome 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.