Thermo Fisher Scientific CIB4 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
ACPSLKIEYA FRIYDFNENG FIDEEDLQRI ILRLLNSDDM SEDLLMDLTN HVLSESDLDN DNMLSFSEFE HAMAKSPDFM NSFRIHFWGC

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 92%

Target Information

CIB4 (calcium and integrin-binding family member 4) is a 185 amino acid protein that contains three EF-hand domains. CIB4 is closely related to CIB, which has one less EF-hand domain and is known to bind to Integrin alpha II beta in platelets, playing a role in signal transduction.
The gene encoding CIB4 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.
Harlequin ichthyosis, a rare and severe skin deformity, is associated with mutations in the ABCA12 gene, while lipid metabolic disorders such as sitosterolemia are linked to defects in ABCG5 and ABCG8 genes. Additionally, Alstrom syndrome, a rare recessive genetic disorder, is caused by mutations in the ALMS1 gene located on chromosome 2.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.