Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI8A4), TrueMAB

Applications

• Western Blot (WB): 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein similar to non-receptor-type protein-tyrosine phosphatases and shares sequence similarity with a Tyr/Ser-protein phosphatase from vaccinia virus.
The bacterially expressed DUSP1 protein exhibits intrinsic phosphatase activity, inactivating MAP kinase by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocytes.
DUSP1 plays a key role in cellular stress response and negative regulation of cell proliferation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.