Thermo Fisher Scientific Human ACE2 (aa1-615) Fc Chimera Recombinant Protein
Human ACE2 단백질(aa1-615)에 Fc 태그가 결합된 재조합 단백질로, HEK293 세포에서 발현됨. ELISA 및 Western blot 등 다양한 분석에 사용 가능. 순도 95% 이상이며 PBS 용액 형태로 제공. SARS-CoV 수용체 연구 및 심혈관 생리학 연구에 적합.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Control (Ctrl)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | HEK293 cells |
| Amino Acid Sequence | Human ACE2 recombinant protein contains amino acids 1–615 with a human Fc tag |
| Tag | Fc-tag |
| Molecular Weight | 110 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >95% by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-87677 has been tested in indirect ELISA.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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