Thermo Fisher Scientific GluR1 Monoclonal Antibody (N355/1), PE
PE 형광 표지된 GluR1 단클론 항체로 인간, 마우스, 랫트 시료에 반응합니다. WB, IHC, ICC/IF 실험에 적합하며, 단백질 G 정제 및 보존제 무첨가 상태로 제공됩니다. GluR1 검출에 특이적이며 GluR2와 교차 반응하지 않습니다.
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Thermo Fisher Scientific GluR1 Monoclonal Antibody (N355/1), PE
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N355/1 |
| Immunogen | Fusion protein amino acids 1–389 (extracellular N-terminus) of rat GluA1/GluR1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932084 |
Additional Formats
Product Specific Information
- 1 µg/mL of MA5-45630 detects GluA1/GluR1 in 20 µg of mouse brain membrane lysate by colorimetric immunoblot using goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 100 kDa.
- Does not cross-react with GluR2.
- Formerly sold as clone S355-1.
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal to an electrical impulse. The receptor then rapidly desensitizes and enters an inactive state with a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization characterized by delayed accumulation of current flux upon continued glutamate application.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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