Thermo Fisher Scientific Androgen Receptor Recombinant Rabbit Monoclonal Antibody (PO00-29)
Thermo Fisher Scientific의 Androgen Receptor Recombinant Rabbit Monoclonal Antibody (PO00-29)는 인간 및 랫트 시료에 반응하며 WB와 IHC(P)에 적합합니다. HEK293 발현 시스템에서 생산된 재조합 단일클론 항체로, 1 mg/mL 농도의 액상 형태로 제공됩니다. 단백질 A로 정제되어 안정적인 신뢰성을 제공합니다.
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Applications
- Western Blot (WB): 1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PO00-29 |
| Immunogen | Synthetic peptide within Human Androgen Receptor aa 300–400/920 (N terminal) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093795 |
Product Specific Information
- Positive control: A549 cell lysate, K562 cell lysate, Rat testis tissue lysate, rat epididymis tissue, human prostate carcinoma tissue, human fallopian tube tissue
- Predicted band size: 99 kDa
- Subcellular Location: Cytoplasm, Nucleus
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling is crucial for development and function of male reproductive organs (prostate, epididymis) and also influences nonreproductive tissues such as muscle, hair follicles, and brain.
Abnormalities in AR signaling are linked to diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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