Thermo Fisher Scientific MYH7 Monoclonal Antibody (MYH7/9184)
Human MYH7 단백질을 표적으로 하는 단클론 항체로, 심근 및 골격근 연구에 적합. IHC(P)에서 1–2 µg/mL로 사용 가능. 단백질 A/G로 정제된 액상 형태이며 PBS+BSA buffer에 보존. 근섬유 내 세포질 위치 검출에 유용.
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Thermo Fisher Scientific MYH7 Monoclonal Antibody (MYH7/9184)
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MYH7/9184 |
| Immunogen | Recombinant fragment (around aa1150–1350) of human MYH7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Skeletal muscle
- Cellular Location: Cytoplasm; myofibril. Thick filaments of the myofibrils.
Target Information
Muscle myosin is a hexameric protein composed of 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits.
The MYH7 gene encodes the beta (slow) heavy chain subunit of cardiac myosin, predominantly expressed in human ventricle and in skeletal muscle rich in slow-twitch type I fibers.
Alterations in MYH7 expression are linked to cardiac contractile velocity changes and various cardiomyopathies, including familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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