Thermo Fisher Scientific IL-2 Monoclonal Antibody (MQ1-17H12), APC, eBioscience

Applications

Tested Application

• Flow Cytometry (Flow)

Tested Dilution

• 0.25 µg/test

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Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 532
• Brilliant UV 395
• Brilliant UV 615
• Brilliant UV 737
• Brilliant Violet 421
• Brilliant Violet 480
• eFluor 450
• FITC
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

Description:
The MQ1-17H12 antibody reacts with human interleukin-2 (IL-2), a 17 kDa T cell growth factor and a major immunoregulatory cytokine. The MQ1-17H12 antibody is a non-neutralizing antibody.

Applications Reported:
MQ1-17H12 has been reported for use in staining of intracellular IL-2.

Applications Tested:
Tested for intracellular staining and flow cytometric analysis of activated human peripheral blood cells. Recommended use ≤ 0.25 µg per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test. Antibody titration is advised for optimal performance.

Excitation/Emission:
633–647 nm / 660 nm (Red Laser)

Filtration:
0.2 µm post-manufacturing filtered.

Target Information

Interleukin 2 (IL-2) is an immuno-modulatory cytokine essential for proliferation of activated T cells and differentiation of B cells, NK cells, monocytes, and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric complex whose gamma chain is shared with IL-4 and IL-7. Monoallelic expression of IL-2 in mature thymocytes represents a unique regulatory mechanism. Mouse gene disruption studies indicate IL-2’s critical role in immune homeostasis and prevention of colitis-like disease.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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