Thermo Fisher Scientific PLK1 Monoclonal Antibody (E.456.6)
PLK1 단백질을 인식하는 Rabbit 모노클로날 항체로, WB, IHC(P), IP 등에 사용 가능. 세포 분열 및 암 연구용으로 최적화. 액상 형태, 비결합(Unconjugated), -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.456.6 |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of human PLK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 38 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10980410 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
PLK1 (Polo-like kinase 1) is a serine/threonine kinase involved in cell mitosis and is regarded as a marker of cell proliferation. It plays a critical role in carcinogenesis. PLK1 acts by binding and phosphorylating proteins that are already phosphorylated on specific motifs recognized by POLO box domains. It phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, and WEE1.
PLK1 plays a key role in centrosome functions and assembly of bipolar spindles by phosphorylating KIZ, NEDD1, and NINL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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