Thermo Fisher Scientific SMAD2 Monoclonal Antibody (G.392.2)
SMAD2 단백질의 N-말단에 특이적인 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫드, 비인간 영장류에 반응하며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G.392.2 |
| Immunogen | Recombinant protein specific to the amino terminus of human Smad2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10984271 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
SMAD2 (also known as MADH2, MAD2) regulates multiple cellular processes such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with TGF-beta receptors through the SMAD anchor for receptor activation, and its translocation into the nucleus is a central event in TGF-beta signaling.
Phosphorylation of threonine 8 in the MH1 domain by ERK1 enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. Upon TGF-beta signaling, SMAD2 is phosphorylated by TGF-beta receptors, leading to dissociation from SARA and association with SMAD4. The SMAD2–SMAD4 complex translocates into the nucleus to regulate transcription. SMAD2 can also be phosphorylated by activin type 1 receptor kinase. Alternatively spliced transcript variants encoding SMAD2 have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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