Thermo Fisher Scientific CBX4 Recombinant Rabbit Monoclonal Antibody (ARC1201)
CBX4 단백질을 인식하는 토끼 단클론 항체로, Western blot, ELISA, IP에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, HEK293 세포에서 발현된 재조합 항체입니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1201 |
| Immunogen | A synthetic peptide corresponding to amino acids 461–560 of human CBX4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849545 |
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, and BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and is a candidate KyoT2-binding protein. It acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation. Depletion of CBX4 reduces cellular resistance to ionizing radiation and is directly involved in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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