Thermo Fisher Scientific L1CAM Monoclonal Antibody (UMAB47), UltraMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

L1CAM (CD171) is an axonal glycoprotein of the immunoglobulin superfamily. Its ectodomain contains several immunoglobulin-like and fibronectin type III domains, linked through a single transmembrane region to a conserved cytoplasmic domain.
L1CAM plays a crucial role in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.