Thermo Fisher Scientific L1CAM Monoclonal Antibody (UMAB47), UltraMAB
L1CAM 단백질을 인식하는 UMAB47 단클론 항체로, Western blot, IHC, ICC, ChIP 등 다양한 응용에 사용 가능. 인간 시료에 반응하며, PBS와 trehalose 완충액에 동결건조 형태로 제공. 신경계 발달 및 세포 부착 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| ChIP assay (ChIP) | Assay-dependent | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB47 |
| Immunogen | Full length human recombinant protein of human L1CAM produced in HEK293T cells (target family: CD171 (L1CAM), UniProt ID: P32004-1, antigen range: 1–1257) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
L1CAM (CD171) is an axonal glycoprotein of the immunoglobulin superfamily. Its ectodomain contains several immunoglobulin-like and fibronectin type III domains, linked through a single transmembrane region to a conserved cytoplasmic domain.
L1CAM plays a crucial role in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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