Thermo Fisher Scientific L1CAM Monoclonal Antibody (UMAB48), UltraMAB
L1CAM 단백질을 표적으로 하는 Mouse Monoclonal Antibody (Clone UMAB48)로, Western Blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성, 고순도 친화 크로마토그래피 정제, 안정적 PBS/BSA/glycerol 저장 버퍼 구성.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB48 |
| Immunogen | Full-length human recombinant protein of human L1CAM produced in HEK293T cells (Target Family: CD171 (L1CAM), UniProt ID: P32004-1, Antigen Range: 1-1257, Antigen Length: 1257) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. Its ectodomain consists of multiple immunoglobulin-like and fibronectin-like type III repeats, linked by a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays a key role in nervous system development, including neuronal migration and differentiation. Mutations in this gene cause three X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus). Alternative splicing of a neuron-specific exon is considered functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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