Thermo Fisher Scientific PHC1 Polyclonal Antibody
PHC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot 및 ELISA에 적합하며, Affinity Chromatography로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 750–940 of human PHC1 (NP_004417.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.18 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914528 |
Product Specific Information
- Positive test controls: A-549, Mouse kidney
- Subcellular location: Nucleus
Immunogen sequence:
FPVGCSQLLK ESEKPLQTGL PTGLTENQSG GPLGVDSPSA ELDKKANLLK CEYCGKYAPA EQFRGSKRFC SMTCAKRYNV SCSHQFRLKR KKMKEFQEAN YARVRRRGPR RSSSDIARAK IQGKCHRGQE DSSRGSDNSS YDEALSPTSP GPLSVRAGHG ERDLGNPNTA PPTPELHGIN PVFLSSNPSR W
Target Information
Polycomb group (PcG) proteins assemble into multimeric protein complexes that maintain the transcriptional repressive state of genes throughout development.
PHC1 (polyhomeotic homolog 1), also known as EDR1, HPH1, or RAE28, is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex.
The PcG PRC1 complex modifies histones, remodels chromatin, and mediates monoubiquination of Histone H2A.
Other constituent proteins include Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, and Ring1b.
PHC1 exists as a homodimer and contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain.
The PHC1 gene is located on human chromosome 12, encoding over 1,100 genes and comprising approximately 4.5% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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