Thermo Fisher Scientific NPRL2 Polyclonal Antibody
NPRL2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA에 사용 가능하며 Human, Mouse, Rat에 반응. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer에 보관, -20°C에서 안정적 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 1–220 of human NPRL2 (NP_006536.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.52 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914531 |
Product Specific Information
- Positive test controls: HL-60, U-937, Mouse brain
- Immunogen sequence:
MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP IVKKLAGYLT TLELESSFVS MEESKQKLVP IMTILLEELN ASGRCTLPID ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFNSQWD LTTQQILPYI DGFRHIQKIS AEADVELNLV
Target Information
NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein containing a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver, and pancreas, with lower expression in lung, kidney, placenta, and heart. NPRL2 is also expressed in most lung cancer cell lines and may function as a tumor suppressor. It plays roles in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathways, and may enhance the therapeutic efficacy of chemotherapy drugs such as cisplatin by resensitizing resistant cells. The gene encoding NPRL2 is conserved among species and expressed as two isoforms due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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