Thermo Fisher Scientific SOX2 (Embryonic Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (SOX2/4267R)

Thermo Fisher Scientific SOX2 (Embryonic Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (SOX2/4267R)

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Antibody stability: 24 months
• Positive Control: MCF-7 cells, human lung or cervical carcinoma
• Cellular Localization: Nucleus

Specificity Comments:
SOX2 is required for stem cell maintenance in the central nervous system and regulates gene expression in the stomach. It stabilizes embryonic stem cells in a pluripotent state by maintaining Oct 3/4 expression levels. SOX2 is associated with aggressive phenotypes of various cancers, including breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. It is expressed in a high percentage of lung squamous cell carcinomas and is an independent favorable prognostic marker.

Target Information

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in embryonic development and cell fate determination. The SOX2 protein is essential for stem-cell maintenance in the central nervous system and regulates gene expression in the stomach. The gene lies within an intron of SOX2 overlapping transcript (SOX2OT). SOX2 may act as a transcriptional activator in complex with other proteins. Mutations in SOX2 are associated with bilateral anophthalmia, optic nerve hypoplasia, and syndromic microphthalmia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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