Thermo Fisher Scientific Human PUMA Synthetic Peptide
인간 PUMA 단백질의 N-말단 15 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20008과 함께 블로킹 펩타이드로 사용 가능. 세포사멸 연구 및 p53 관련 경로 분석에 유용. 순도 높은 액상 형태로 제공되며, PBS 버퍼에 보관.
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to the 15 amino acid N-terminus of human PUMA.
PEP-0128 can be used as a blocking peptide with polyclonal antibody PA5-20008.
Target Information
PUMA is one of the pro-apoptotic Bcl-2 family members, including Bax and Noxa, which are also transcriptional targets of p53.
The PUMA gene encodes two BH3 domain-containing proteins, PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to mitochondria, and induce cytochrome c release and apoptosis in response to p53.
PUMA may act as a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduces the apoptotic response to p53, suggesting that PUMA plays a key role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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