Thermo Fisher Scientific Human PUMA Synthetic Peptide
인간 PUMA 단백질의 C-말단 14개 아미노산 서열에 대응하는 합성 펩타이드입니다. 항체 PA5-20007의 블로킹 펩타이드로 사용 가능하며, p53 관련 세포사멸 연구에 활용됩니다. 정제된 액상 형태로, PBS 버퍼 내 0.1% BSA 및 0.02% sodium azide를 함유합니다.
- 판매단위
- pk
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Thermo Fisher Scientific Human PUMA Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human PUMA.
PEP-0127 can be used as a blocking peptide with polyclonal antibody PA5-20007.
Target Information
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53.
PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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