Thermo Fisher Scientific Human Bcl-rambo Synthetic Peptide
인간 Bcl-rambo 단백질의 중심부 15개 아미노산 서열 기반 합성 펩타이드. PA5-20000 항체의 블로킹 펩타이드로 사용 가능. 세포자멸사 연구용으로 적합하며, 정제된 액상 형태로 제공. PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human Bcl-rambo.
PEP-0122 can be used as a blocking peptide with polyclonal antibody PA5-20000.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer. Members of the Bcl-2 family are critical regulators of apoptosis, characterized by conserved Bcl-2 homology (BH) domains.
A novel member, Bcl-rambo, was identified as a mitochondrial protein whose overexpression induces apoptosis, which can be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2.
Bcl-rambo shares homology with anti-apoptotic Bcl-2 members but contains a unique 250 amino acid insertion before its C-terminal membrane anchor. This region alone can efficiently induce apoptosis, suggesting that Bcl-rambo may be involved in distinct pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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