Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody
Rabbit polyclonal antibody against human MRGPRX2 for IHC and ELISA applications. Recognizes C-terminal cytoplasmic domain. Recommended citrate buffer antigen retrieval. High species identity; ideal for nociceptor function studies. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 20 µg/mL
- Recommended: Antigen retrieval using citrate buffer (pH 6.0)
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human MRGPRX2 / MRGX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2550391 |
Product Specific Information
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis:
- Human, Chimpanzee, Gorilla (100%)
- Orangutan (94%)
- Gibbon, Monkey (88%)
Target Information
Orphan receptor probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 appears to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation, locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca²⁺ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Expression is limited, with highest levels in dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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