Thermo Fisher Scientific MMP13 Polyclonal Antibody
Human MMP13 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC(P)]: 17 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminus of human MMP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550388 |
Product Specific Information
- Percent identity with other species (BLAST analysis):
- Human (100%)
- Gorilla, Gibbon, Monkey (94%)
- Marmoset (83%)
- For IHC(P): Use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
MMP13 (collagenase 3) plays a role in the degradation of extracellular matrix proteins, including fibrillar collagen, fibronectin, tenascin-C (TNC), and aggrecan (ACAN).
It cleaves triple-helical collagens (types I, II, and III) with highest activity toward soluble type II collagen, and can also degrade collagen types IV, XIV, and X.
MMP13 is involved in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification.
It is required for normal embryonic bone development and ossification.
Mutations in the MMP13 gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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