Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody (790A28G2)
인간 IL-8(CXCL8)을 인식하는 Mouse IgG1 단일클론 항체로, ELISA 검출용에 적합합니다. 정제된 재조합 IL-8을 면역원으로 제작되었으며, Protein A로 정제되었습니다. PBS/BSA 완충액에 보관되며 4°C에서 안정적입니다.
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Applications
- ELISA (ELISA): Assay-dependent
- View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 790A28G2 |
| Immunogen | Purified recombinant human IL-8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4, with 5 mg/mL BSA |
| Contains | 0.5 mg/mL sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Dry ice |
| RRID | AB_2536260 |
Additional Formats
Product Specific Information
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 790A 28G2 1E3.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, bound by receptors IL-8RA and IL-8RB. IL-8 acts as a chemoattractant and potent angiogenic factor. Its expression and secretion are induced by various inflammatory stimuli in cells such as macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
IL-8, first isolated from osteosarcoma cells, contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a gene cluster on chromosome 4q. Research indicates IL-8 contributes to tumor angiogenesis and growth, and may play a role in bronchiolitis pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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