Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody (790A28G2)

Applications

• ELISA (ELISA): Assay-dependent
• View 6 publications

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 790A 28G2 1E3.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, bound by receptors IL-8RA and IL-8RB. IL-8 acts as a chemoattractant and potent angiogenic factor. Its expression and secretion are induced by various inflammatory stimuli in cells such as macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.

IL-8, first isolated from osteosarcoma cells, contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a gene cluster on chromosome 4q. Research indicates IL-8 contributes to tumor angiogenesis and growth, and may play a role in bronchiolitis pathogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.