Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody (790A28G2), Biotin

Applications

• ELISA (Sandwich ELISA): Assay-dependent
  Recommended as a detection antibody in Sandwich ELISA applications.

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Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

• Recommended as a detection antibody in Sandwich ELISA applications.
• This clone can also be referred to as clone number 790A 28G2 1E3.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, bound by the cell surface receptors IL-8RA and IL-8RB.
IL-8 functions as a chemoattractant and potent angiogenic factor. Its expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells.
In endothelial cells, IL-8 is stored in Weibel-Palade bodies. Originally isolated from osteosarcoma cells, IL-8 contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous names include NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related chemokines form a gene cluster on chromosome 4q.
IL-8 is implicated in tumor angiogenesis and bronchiolitis pathogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.