Thermo Fisher Scientific Phospho-FADD (Ser41) Polyclonal Antibody
FADD 단백질의 Ser41 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot 및 immunocytochemistry에 적합하며, 인산화된 FADD의 내인성 수준을 확인 가능. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Thermo Fisher Scientific Phospho-FADD (Ser41) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FADD (Accession Q13158), corresponding to amino acid residues around phosphorylated Ser41 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817096 |
Product Specific Information
Antibody detects endogenous levels of FADD only when phosphorylated at Ser41.
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signals. Through its C-terminal death domain, it can be recruited by TNFRSF6/Fas receptor, TNFRSF25, and TNFSF10/TRAIL receptor, participating in death signaling initiated by these receptors. Interaction with these receptors unmasks the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice suggest its importance in early T cell development.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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