Thermo Fisher Scientific CIS Recombinant Rabbit Monoclonal Antibody (5H6L11)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Feline, Rabbit, Rat, Mouse, and Goat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

Target Information

CIS contains SH2 and SOCS box domains and belongs to the cytokine-induced STAT inhibitor (CIS) protein family, also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI). CIS family members act as cytokine-inducible negative regulators of cytokine signaling. Expression of this gene can be induced by IL2, IL3, GM-CSF, and EPO in hematopoietic cells. Proteasome-mediated degradation of CIS is involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.