Thermo Fisher Scientific Phospho-FOXO4 (Thr28) Recombinant Rabbit Monoclonal Antibody (12H2L20)

Applications

Western Blot (WB)

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Goat, Pig, Bovine, Dog, Rat, and Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7)) and belongs to the O class of forkhead/winged helix family of transcription factors, along with FOXO1, FOXO3, and FOXO6.

FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of Akt, another downstream target of the Insulin/IGF1 pathway, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3, resulting in its exit from the nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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