Thermo Fisher Scientific Bim Recombinant Rabbit Monoclonal Antibody (8H1L4)

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Rabbit, and Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

BIM belongs to the BCL-2 protein family. These family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.

The encoded protein contains a Bcl-2 homology domain 3 (BH3) and interacts with other BCL-2 family members such as BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis.

Transgenic mouse studies indicate that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.