Thermo Fisher Scientific PSMC2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT

Positive Samples:
HepG2, SW620, BT474, DUCAR3, 293T, mouse spleen, mouse brain, rat testis, rat liver, BT-474, OVCAR3, NCI-H460

Cellular Location:
Cytoplasm, Nucleus, P-body

Target Information

Proteolytic degradation is essential for maintaining proper levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway mediates most protein degradation in the eukaryotic cytosol and nucleus, while others are processed via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome (~2.5 MDa) consists of a 20S proteolytic core and 19S regulatory subunits that recognize ubiquitinated proteins, unfold them, and translocate them into the 20S lumen.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.