Thermo Fisher Scientific PSMC2 Polyclonal Antibody
PSMC2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 1–160 of human PSMC2 (NP_002794.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2807826 |
Product Specific Information
Immunogen sequence:
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT
Positive Samples:
HepG2, SW620, BT474, DUCAR3, 293T, mouse spleen, mouse brain, rat testis, rat liver, BT-474, OVCAR3, NCI-H460
Cellular Location:
Cytoplasm, Nucleus, P-body
Target Information
Proteolytic degradation is essential for maintaining proper levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway mediates most protein degradation in the eukaryotic cytosol and nucleus, while others are processed via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome (~2.5 MDa) consists of a 20S proteolytic core and 19S regulatory subunits that recognize ubiquitinated proteins, unfold them, and translocate them into the 20S lumen.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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