Thermo Fisher Scientific Phospho-CD31 (Tyr713) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of CD31 only when phosphorylated at Tyrosine 713.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM). Upon kinase-mediated phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells. The N-terminal Ig-like domain of CD31 mediates homophilic binding, playing an important role in cell-cell interactions.
It is a multifunctional molecule involved in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis.
CD31 is one of the key regulatory molecules in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.