Thermo Fisher Scientific Phospho-CREB (Ser142) Polyclonal Antibody
Phospho-CREB (Ser142) 특이적 인식 항체로, Western blot, IHC, ICC/IF에 적합. 사람, 생쥐, 랫트 반응성. 액상 형태로 1 mg/mL 농도, -20°C 보관. CREB의 Ser142 인산화 상태를 검출하여 신호전달 및 전사 활성 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-CREB (Ser142) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CREB1 (Accession P16220), corresponding to amino acid residues around phosphorylated Ser142 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816284 |
Product Specific Information
This antibody detects endogenous levels of CREB only when phosphorylated at Serine 142.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals, including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors.
Activation of CREB is dependent upon phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1.
Although CREB binds DNA independent of phosphorylation, only the phosphorylated form functions as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator, interacts with CREB near serine 133.
CREB participates in processes such as circadian rhythm synchronization, adipocyte differentiation, and learning and memory. In humans, the CREB gene is located on chromosome 2q.
Diseases associated with CREB dysfunction include Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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