Thermo Fisher Scientific EDAR Chimeric Recombinant Rabbit Monoclonal Antibody (EDAR12)

Applications and Tested Dilution

Product Specifications

Immunogen

EDAR12 was prepared by immunizing female OVE1B mice (with the Edar gene deleted) subcutaneously with mouse EDAR-Fc. Positive hybridoma clones were screened for binding mEDAR by ELISA.

Product Specific Information

EDAR12 recognises and binds to CRD1 of the extracellular domain of mouse EDAR.
EDAR3 cross-reacts with EDAR derived from human, dog, rat, and chicken when EDAR is fused to the glycosylphosphatidylinositol anchor of TRAILR3.
EDAR is the receptor for the TNF family ligand EDA1, a type II transmembrane protein possessing a collagen-like domain and a C-terminal TNF-homology domain.
EDAR plays a crucial role in the proper development of skin appendages including hair, teeth, and eccrine sweat glands.
Loss-of-function mutations in the Eda gene are known to cause XLHED (X-linked hypohidrotic ectodermal dysplasia), leading to abnormal development.

Target Information

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways.
It is essential for the development of hair, teeth, and other ectodermal derivatives.
Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.