Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)
Thermo Fisher Scientific의 c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)은 다양한 면역분석(WB, IHC, ICC, IP)에 적합한 항체입니다. 인간 유래 HEK293 세포에서 발현된 재조합 단일클론 항체로, c-Myc 단백질의 410-419 아미노산 서열(EQKLISEEDL)을 인식합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA551723
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG2, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 from the C-terminus of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in amino acids 410–419 of the human c-Myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays critical roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates these processes.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc induces apoptosis in certain cell types. Antibodies against c-Myc epitopes recognize Myc-tagged fusion proteins at either the N- or C-terminus. Amplification or translocation of the c-Myc gene is associated with several human cancers, including lung, breast, colon, and Burkitt’s lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.