Thermo Fisher Scientific Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor 488
Alexa Fluor 488로 표지된 Lamin B2 단일클론 항체로, 인간, 생쥐, 닭, 랫트 시료에 반응합니다. 면역세포화학(ICC/IF)에 적합하며, 단백질 A로 정제된 액상 제품입니다. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- MA332100A488
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E-3 |
| Immunogen | Extracts from chicken nuclei |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2663151 |
Additional Formats
- Unconjugated (Cat. No. 33-2100)
- Alexa Fluor 555 (Cat. No. MA3-32100-A555)
- Alexa Fluor 647 (Cat. No. MA3-32100-A647)
- Custom conjugation available upon request
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, all produced from the same gene via alternative splicing.
B-type lamins include lamin B1 and lamin B2, produced from distinct genes.
Mutations in A-type lamins are associated with several dominant genetic disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a regulatory role in differential gene expression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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