Thermo Fisher Scientific Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor 647
Thermo Fisher의 Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor 647은 핵 라민 B2 단백질 검출용 형광 표지 항체입니다. 인간, 생쥐, 닭, 랫트 시료에 반응하며 ICC/IF에 적합합니다. Alexa Fluor 647 형광으로 650/671 nm에서 우수한 감도를 제공합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E-3 |
| Immunogen | Extracts from chicken nuclei |
| Conjugate | Alexa Fluor™ 647 |
| Excitation / Emission Max | 650 / 671 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662575 |
Additional Formats
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, which arise from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, arising from distinct genes.
Mutations in A-type lamins are associated with rare dominant genetic disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulating differential gene expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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