Thermo Fisher Scientific TCR V beta 3 Monoclonal Antibody (JOVI.1)
TCR V beta 3 단백질을 인식하는 JOVI.1 단클론 항체로, IHC(F), Flow Cytometry, IP 등 다양한 연구용 응용에 적합. 비결합형 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 가능. 마우스 IgG2a 아이소타입 기반.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | Assay-dependent | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JOVI.1 |
| Immunogen | Thymus, spleen, and mesenteric lymph nodes isolated from a mouse transgenic for human Vβ3 TcR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1960897 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The T cell receptor (TCR) plays a critical role in distinguishing self from non-self peptides presented by MHC class II molecules, enabling an effective adaptive immune response. Recognition of self-peptides by TCRs has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Bacterial superantigens can engage TCRs and cause toxic shock syndrome. Autoantibodies against V beta segments of TCRs have been identified in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially regulating TH1-mediated inflammatory reactions.
Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive, SP). A small population lacks both (double negative, DN), which can increase in autoimmune or immunodeficiency conditions. Gamma-delta T cells, found mainly in epithelial tissues, exhibit limited TCR diversity and distinct antigen recognition, contributing to antitumor and immunoregulatory activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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