Thermo Fisher Scientific TCR V beta 3 Monoclonal Antibody (JOVI.1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The T cell receptor (TCR) plays a critical role in distinguishing self from non-self peptides presented by MHC class II molecules, enabling an effective adaptive immune response. Recognition of self-peptides by TCRs has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Bacterial superantigens can engage TCRs and cause toxic shock syndrome. Autoantibodies against V beta segments of TCRs have been identified in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially regulating TH1-mediated inflammatory reactions.

Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive, SP). A small population lacks both (double negative, DN), which can increase in autoimmune or immunodeficiency conditions. Gamma-delta T cells, found mainly in epithelial tissues, exhibit limited TCR diversity and distinct antigen recognition, contributing to antitumor and immunoregulatory activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.