Thermo Fisher Scientific AEG1 Polyclonal Antibody
Western blot과 Immunoprecipitation에 적합한 Rabbit Polyclonal 항체. 인간 Astrocyte Elevated Gene-1(300–350 aa) 영역을 면역원으로 제작. 비결합형(Unconjugated) 액상 형태로 제공되며, 4°C에서 보관. Metadherin 단백질 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 300 and 350 of human Astrocyte Elevated Gene-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation rather than acting as a structural component.
Metadherin is overexpressed in breast cancer tissue and xenografts, with much lower expression in normal breast tissue. It binds to lung vasculature, one of the common sites of breast cancer metastasis, via its C-terminal extracellular domain. Blocking this domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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