Thermo Fisher Scientific IGF2R Polyclonal Antibody
Human 및 비인간 영장류에 반응하는 Rabbit Polyclonal IGF2R 항체. 면역세포화학(ICC/IF)에 4 µg/mL로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C 권장. IGF-II 및 mannose 6-phosphate 결합 특성 연구용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from residues 700–800 of Human Mannose 6 Phosphate Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982449 |
Product Specific Information
- Heat-mediated antigen retrieval recommended prior to tissue staining.
- This antibody is predicted to react with mouse based on sequence homology.
- Store antibody at 4ºC for 1–2 weeks. For long-term storage, store at -20ºC.
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported within the cell by approximately 300 kDa cation-independent mannose 6-phosphate receptors (CI-MPR).
These receptors participate in two interconnected cycles:
- Biosynthetic cycle: MPR transports newly synthesized lysosomal enzymes from the trans-Golgi network to late endosomes or early lysosomes.
- Endocytic cycle: Transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes.
MPRs cycle between compartments every 3 hours, with most found in late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.
The receptor also binds type II insulin-like growth factor (IGF-II) simultaneously with man6P.
A truncated soluble form (~240 kDa) representing the extracellular domain circulates in serum and retains ligand-binding capability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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