Thermo Fisher Scientific ZNF496 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 405-548. Recombinant protein control fragment (Product #RP-109712). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZNF496,uniProtId:Q96IT1-1,ncbiNodeId:9606,antigenRange:405-548,antigenLength:587,antigenImageFileName:PA5-144735_ZNF496_Q96IT1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144735_ZNF496_Q96IT1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092199

Product Specific Information

Immunogen sequence: SYVCPNCGKI FRWRVNFIRH LRSRREQEKP HECSVCGELF SDSEDLDGHL ESHEAQKPYR CGACGKSFRL NSHLLSHRRI HLQPDRLQPV EKREQAASED ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKD

Antigen sequence identity: Mouse 78%; Rat 74%

Target Information

ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.