Thermo Fisher Scientific Integrin beta 7 Chimeric Recombinant Rabbit Monoclonal Antibody (FIB504)
Integrin beta 7에 특이적인 재조합 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. ICC/IF, Flow Cytometry, Inhibition Assay에 사용 가능하며, HEK293 세포에서 발현된 Rabbit IgG 형태입니다. 단백질 A로 정제되어 높은 순도와 안정성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Reference |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Inhibition Assays (IA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | FIB504 |
| Immunogen | FIB504 was prepared by immunizing rats with TK1 cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074456 |
Product Specific Information
FIB504 recognizes an epitope on integrin beta-7 subunit that overlaps completely with the epitopes defined by Fib27 and Fib30, and partially with those defined by FIB21 and FIB22.
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
- Ligands for LPAM-1: VCAM-1 (CD106), MAdCAM-1, fibronectin
- Ligand for HML-1: E-cadherin (CD324)
Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells, promoting transmigration of leukocytes to extravascular spaces during inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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