Thermo Fisher Scientific NBL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunohistochemistry (IHC)

5-15 µg/mL

-

Neutralization (Neu)

Assay-Dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human DAN Ala17-Asp180 (Ala36Arg) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NBL1,uniProtId:P41271-1,ncbiNodeId:9606,antigenRange:17-180,antigenLength:181,antigenImageFileName:PA5-47972_NBL1_P41271-1_Goat.svg,antigenImageFileNamePDP:PA5-47972_NBL1_P41271-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2608812

Product Specific Information

In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse (rm) DAN is observed and less than 1% cross-reactivity with recombinant chicken Caronte, rmGremlin, and recombinant human Cerberus 1 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.